Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex

of molecules that are capable of modulating such a †Department of Medicine phenomenon are integrins, the major cell surface recepChildren’s Hospital and tors for the ECM that mediate cell–ECM and cell–cell Department of Pediatrics adhesive interactions. Integrins are uniquely suitable for Harvard Medical School this purpose, since (1) different integrin receptors disBoston, Massachusetts 02115 play different adhesive properties, (2) different integrins ‡Departments of Biology may regulate different intracellular signal transduction and Neuroscience pathways and thus, different modes of adhesion-induced Pennsylvania State University changes in cell physiology, and (3) integrins are capable University Park, Pennsylvania 16803 of synergizing with other cell surface receptor systems